Re-examining LGBT Resources on College Counseling Center Websites: An Over-time and Cross-country Analysis

Lesbian, gay, bisexual, and transgender (LGBT) students continue to perceive a hostile climate on college campuses. For students facing these challenges, the university college counseling center website (CCW) may serve as a critical resource. This study provides an updated content analysis of the prevalence of LGBT communication on CCWs. Results showed that there remains a lack of LGBT-specific information about services provided on US CCWs. Furthermore, over-time analyses of 2008 and 2013 data showed that there have been no significant increases in any LGBT communication, and CCWs from religious schools continue to provide significantly less LGBT-related communication than nonreligious institutions. Separate analyses of UK CCWs showed that these websites were more likely than US CCWs to make any mention of LGBT issues but less likely to note group counseling services, links to LGBT-specific pamphlets, and educational outreach services offered. Overall, given attractive features of online health information, as well as the extent that students value CCWs, institutions must pursue stronger efforts to promote LGBT-related web counseling information. [ABSTRACT FROM AUTHOR

More on Massive 3D Supergravity

Completing earlier work on three dimensional (3D) N=1 supergravity with curvature-squared terms, we construct the general supergravity extension of cosmological massive gravity theories. We expand about supersymmetric anti-de Sitter vacua, finding the conditions for bulk unitarity and the critical points in parameter space at which the spectrum changes. We discuss implications for the dual conformal field theory.Comment: v1 : 53 pages, 1 figure; v2 : significantly shortened, 42 p., version published in Class. Quant. Gra

Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.

Peptidylarginine deiminase IV (PADI4) catalyzes the conversion of positively charged arginine and methylarginine residues to neutrally charged citrulline, and this activity has been linked to the repression of a limited number of target genes. To broaden our knowledge of the regulatory potential of PADI4, we utilized chromatin immunoprecipitation coupled with promoter tiling array (ChIP-chip) analysis to more comprehensively investigate the range of PADI4 target genes across the genome in MCF-7 breast cancer cells. Results showed that PADI4 is enriched in gene promoter regions near transcription start sites (TSSs); and, surprisingly, this pattern of binding is primarily associated with actively transcribed genes. Computational analysis found potential binding sites for Elk-1, a member of the ETS oncogene family, to be highly enriched around PADI4 binding sites; and coimmunoprecipitation analysis then confirmed that Elk-1 physically associates with PADI4. To better understand how PADI4 may facilitate gene transactivation, we then show that PADI4 interacts with Elk-1 at the c-Fos promoter and that, following Epidermal Growth Factor (EGF) stimulation, PADI4 catalytic activity facilitates Elk-1 phosphorylation, histone H4 acetylation, and c-Fos transcriptional activation. These results define a novel role for PADI4 as a transcription factor co-activator

A spin-4 analog of 3D massive gravity

A 6th-order, but ghost-free, gauge-invariant action is found for a 4th-rank symmetric tensor potential in a three-dimensional (3D) Minkowski spacetime. It propagates two massive modes of spin 4 that are interchanged by parity, and is thus a spin-4 analog of linearized "new massive gravity". Also found are ghost-free spin-4 analogs of linearized "topologically massive gravity" and "new topologically massive gravity", of 5th- and 8th-order respectively.Comment: 16 pages, v2 : version published in Class. Quant. Gra

Cosmological Perturbations in a Big Crunch/Big Bang Space-time

A prescription is developed for matching general relativistic perturbations across singularities of the type encountered in the ekpyrotic and cyclic scenarios i.e. a collision between orbifold planes. We show that there exists a gauge in which the evolution of perturbations is locally identical to that in a model space-time (compactified Milne mod Z_2) where the matching of modes across the singularity can be treated using a prescription previously introduced by two of us. Using this approach, we show that long wavelength, scale-invariant, growing-mode perturbations in the incoming state pass through the collision and become scale-invariant growing-mode perturbations in the expanding hot big bang phase.Comment: 47 pages, 4 figure

Evaluating of HPV-DNA ISH as an adjunct to p16 testing in oropharyngeal cancer

© 2020 Jeffrey Chi. Aim: Current guidelines recommend p16 immunohistochemistry (IHC) for testing human papillomavirus (HPV) in oropharyngeal carcinoma (OPSCC). We evaluated the value of adding DNA in situ hybridization (ISH) to p16 IHC. Methods: Fifty patients with OPSCC were analyzed. Concordance between HPV-DNA ISH and p16 IHC was measured by Gwet\u27s agreement coefficient. Results: p16 IHC was positive in 35/48 (72.9%), negative in 8/48 (16.7%) patients. Wide spectrum DNA-ISH was positive in 9/23 (39%) and negative in 14/23 (60.9%) patients. High-risk 16/18 (HR) HPV DNA-ISH was positive in 11/23 (47.8%) and negative in 12 (52.2%) patients. The agreement between HPV DNA-ISH and p16 IHC is fair (Gwet\u27s AC1 = 0.318). Conclusion: The agreement between p16 IHC and HPV-DNA ISH was fair. However, ISH sensitivity was low. Our findings add to the current data that p16 IHC testing is reliable and may be enough as a stand-alone test for HPV detection in OPSCC. Current testing guidelines recommend p16 immunochemistry (IHC) for detecting human papillomavirus (HPV) in oropharyngeal cancer (OPSCC). We evaluated the value of adding HPV DNA in situ hybridization (ISH) to p16 IHC. Fifty patients with OPSCC were analyzed. p16 IHC was positive in 72.9% of patients and DNA-ISH was positive in 39% of patients when wide spectrum probe was used and positive in 47.8% of patients when high-risk probe was used. The agreement between the two tests was fair. However, DNA-ISH sensitivity was low. p16 IHC may be enough as a stand-alone test for detection of HPV in OPSCC

Inflationary solutions in the brane-world and their geometrical interpretation

We consider the cosmology of a pair of domain walls bounding a five-dimensional bulk space-time with negative cosmological constant, in which the distance between the branes is not fixed in time. Although there are strong arguments to suggest that this distance should be stabilized in the present epoch, no such constraints exist for the early universe and thus non-static solutions might provide relevant inflationary scenarios. We find the general solution for the standard ansatz where the bulk is foliated by planar-symmetric hypersurfaces. We show that in all cases the bulk geometry is that of anti-de Sitter (AdS_5). We then present a geometrical interpretation for the solutions as embeddings of two de Sitter (dS_4) surfaces in AdS_5, which provide a simple interpretation of the physical properties of the solutions. A notable feature explained in the analysis is that two-way communication between branes expanding away from one another is possible for a finite amount of time, after which communication can proceed in one direction only. The geometrical picture also shows that our class of solutions (and related solutions in the literature) are not completely general, contrary to some claims. We then derive the most general solution for two walls in AdS_5. This includes novel cosmologies where the brane tensions are not constrained to have opposite signs. The construction naturally generalizes to arbitrary FRW cosmologies on the branes.Comment: 24 pages, 9 figure

Constraining compactness and magnetic field geometry of X-ray pulsars from the statistics of their pulse profiles

The light curves observed from X-ray pulsars and magnetars reflect the radiation emission pattern, the geometry of the magnetic field, and the neutron star compactness. We study the statistics of X-ray pulse profiles in order to constrain the neutron star compactness and the magnetic field geometry. We collect the data for 124 X-ray pulsars, which are mainly in high-mass X-ray binary systems, and classify their pulse profiles according to the number of observed peaks seen during one spin period, dividing them into two classes, single- and double-peaked. We find that the pulsars are distributed about equally between both groups. We also compute the probabilities predicted by the theoretical models of two antipodal point-like spots that emit radiation according to the pencil-like emission patterns. These are then compared to the observed fraction of pulsars in the two classes. Assuming a blackbody emission pattern, it is possible to constrain the neutron star compactness if the magnetic dipole has arbitrary inclinations to the pulsar rotational axis. More realistic pencil-beam patterns predict that 79% of the pulsars are double-peaked independently of their compactness. The theoretical predictions can be made consistent with the data if the magnetic dipole inclination to the rotational axis has an upper limit of 40+/-4 deg. We also discuss the effect of limited sensitivity of the X-ray instruments to detect weak pulses, which lowers the number of detected double-peaked profiles and makes the theoretical predictions to be consistent with the data even if the magnetic dipole does have random inclinations. This shows that the statistics of pulse profiles does not allow us to constrain the neutron star compactness. In contrast to the previous claims by Bulik et al. (2003), the data also do not require the magnetic inclination to be confined in a narrow interval.Comment: 14 pages, 10 figures, Astronomy and Astrophysics, in pres

Final results of the EDELWEISS-II WIMP search using a 4-kg array of cryogenic germanium detectors with interleaved electrodes

The EDELWEISS-II collaboration has completed a direct search for WIMP dark matter with an array of ten 400-g cryogenic germanium detectors in operation at the Laboratoire Souterrain de Modane. The combined use of thermal phonon sensors and charge collection electrodes with an interleaved geometry enables the efficient rejection of gamma-induced radioactivity as well as near-surface interactions. A total effective exposure of 384 kg.d has been achieved, mostly coming from fourteen months of continuous operation. Five nuclear recoil candidates are observed above 20 keV, while the estimated background is 3.0 events. The result is interpreted in terms of limits on the cross-section of spin-independent interactions of WIMPs and nucleons. A cross-section of 4.4x10^-8 pb is excluded at 90%CL for a WIMP mass of 85 GeV. New constraints are also set on models where the WIMP-nucleon scattering is inelastic.Comment: 23 pages, 5 figures; matches published versio